Experimental Autoimmune Neuritis

An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)

Also Known As:

Neuritis, Autoimmune, Experimental; EAN (Experimental Allergic Neuritis); EAN (Experimental Autoimmune Neuritis); Experimental Allergic Neuritis; Experimental Autoimmune Neuropathy; Neuritis, Experimental Autoimmune; Autoimmune Neuropathies, Experimental; Autoimmune Neuropathy, Experimental; Experimental Autoimmune Neuropathies; Neuropathies, Experimental Autoimmune; Neuropathy, Experimental Autoimmune; Allergic Neuritis, Experimental; Autoimmune Neuritis, Experimental; Neuritis, Experimental Allergic

Nervous System Diseases: 14178
- Neuromuscular Diseases: 2005
  - Peripheral Nervous System Diseases: 11383
    - Neuritis: 1138
      - Experimental Autoimmune Neuritis: 483
- Autoimmune Diseases of the Nervous System: 1461
  - Experimental Nervous System Autoimmune Disease: 33
    - Experimental Autoimmune Neuritis: 483
Immune System Diseases: 4321
- Autoimmune Diseases: 34618
  - Autoimmune Diseases of the Nervous System: 1461
    - Experimental Nervous System Autoimmune Disease: 33
      - Experimental Autoimmune Neuritis: 483

Edeltraud Lüneberg Selected Research

Edeltraud Lüneberg Research Topics

Disease

Drug/Important Bio-Agent (IBA)